Pub. Date : 2009 Nov
PMID : 19661164
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, dermatan sulfate structure was evaluated after downregulating or increasing dermatan 4-O-sulfotransferase 1 (D4ST-1) expression. | Dermatan Sulfate | carbohydrate sulfotransferase 14 | Homo sapiens |
| 2 | Analysis of the dermatan sulfate chains showed that D4ST-1 is essential for the biosynthesis of the disulfated structure iduronic acid-2-O-sulfate-N-acetylgalactosamine-4-O-sulfate, thus confirmed to be strictly connected with the iduronic acid blocks. | Dermatan Sulfate | carbohydrate sulfotransferase 14 | Homo sapiens |
| 3 | In conclusion, D4ST-1 is a key enzyme and is indispensable in the formation of important functional domains in dermatan sulfate and cannot be compensated by other 4-O-sulfotransferases. | Dermatan Sulfate | carbohydrate sulfotransferase 14 | Homo sapiens |