Pub. Date : 2009 Sep 1
PMID : 19657231
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, we found that thrombopoietin (TPO) induces the generation of mitochondrial ROS. | Reactive Oxygen Species | thrombopoietin | Homo sapiens |
| 2 | Previously, we found that thrombopoietin (TPO) induces the generation of mitochondrial ROS. | Reactive Oxygen Species | thrombopoietin | Homo sapiens |
| 3 | Interestingly, the TPO-induced production of mitochondrial ROS promotes the activation of HIF-1. | Reactive Oxygen Species | thrombopoietin | Homo sapiens |
| 4 | Based on these findings, we speculated that TPO-activated HIF-1 functions as a feedback mechanism to block the overproduction of ROS following TPO stimulation. | Reactive Oxygen Species | thrombopoietin | Homo sapiens |
| 5 | Based on these findings, we speculated that TPO-activated HIF-1 functions as a feedback mechanism to block the overproduction of ROS following TPO stimulation. | Reactive Oxygen Species | thrombopoietin | Homo sapiens |
| 6 | Inhibition of either HIF-1 or PDK-1 resulted in the increased production of ROS following TPO stimulation. | Reactive Oxygen Species | thrombopoietin | Homo sapiens |