Title : Effects of mixtures of polychlorinated biphenyls, methylmercury, and organochlorine pesticides on hepatic DNA methylation in prepubertal female Sprague-Dawley rats.

Pub. Date : 2009 Jul-Aug

PMID : 19636072






1 Functional Relationships(s)
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1 Hepatic analysis revealed that the mRNA abundance for DNA methyltransferase (DNMT)-1, -3a, and -3b were significantly reduced by the high dose of PCB, that the high dose of MeHg also reduced mRNA levels for DNMT-1, and -3b, but that OCP had no significant effects compared with control. 5,10,15,20-tetra(3,5-(nido-carboranylmethyl)phenyl)porphyrin pyruvate carboxylase Rattus norvegicus