Title : Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR).

Pub. Date : 2009 Oct 1

PMID : 19631710






2 Functional Relationships(s)
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1 PentaBDE mix and HBCD have recently been found to induce cytochrome P450 (CYP) 3 enzymes in rat liver. pentabromodiphenyl ether cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
2 In this study we tested both technical pentaBDE mix and HBCD for their potency to induce CYP3A enzymes in rat hepatocytes in primary culture, and in rat H4IIE and human HepG2 hepatoma cells. pentabromodiphenyl ether cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus