Title : XIAP discriminates between type I and type II FAS-induced apoptosis.

Pub. Date : 2009 Aug 20

PMID : 19626005






2 Functional Relationships(s)
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1 In type I cells, such as lymphocytes, activation of "effector caspases" by FAS-induced activation of caspase-8 suffices for cell killing, whereas in type II cells, including hepatocytes and pancreatic beta-cells, caspase cascade amplification through caspase-8-mediated activation of the pro-apoptotic BCL-2 family member BID (BH3 interacting domain death agonist) is essential. ammonium ferrous sulfate BH3 interacting domain death agonist Homo sapiens
2 In type I cells, such as lymphocytes, activation of "effector caspases" by FAS-induced activation of caspase-8 suffices for cell killing, whereas in type II cells, including hepatocytes and pancreatic beta-cells, caspase cascade amplification through caspase-8-mediated activation of the pro-apoptotic BCL-2 family member BID (BH3 interacting domain death agonist) is essential. ammonium ferrous sulfate BH3 interacting domain death agonist Homo sapiens