Title : Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

Pub. Date : 2009 Jul 21

PMID : 19622833






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that administration of l-DOPA in a mouse model of Parkinsonism led to dopamine D1 receptor-mediated activation of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which is implicated in several forms of synaptic plasticity. Levodopa mechanistic target of rapamycin kinase Homo sapiens
2 We show that administration of l-DOPA in a mouse model of Parkinsonism led to dopamine D1 receptor-mediated activation of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which is implicated in several forms of synaptic plasticity. Levodopa mechanistic target of rapamycin kinase Homo sapiens