Title : Thwarting dyskinesia by targeting mTORC1.

Pub. Date : 2009 Jul 21

PMID : 19622830






1 Functional Relationships(s)
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1 In a mouse model of Parkinson"s disease, new evidence shows that l-DOPA, which is used to treat the symptoms of the disease but also causes dyskinesia, results in a persistent activation of the protein kinase mTOR (mammalian target of rapamycin) in a subset of striatal medium spiny neurons. Levodopa mechanistic target of rapamycin kinase Homo sapiens