Pub. Date : 2009 Dec
PMID : 19614891
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 2 | The cytochrome P450 enzyme CYP2C8 appears to have a major role in pioglitazone metabolism. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 3 | The present study was conducted to further clarify the role of individual CYPs and of the CYP2C8/9 polymorphisms in the primary metabolism of pioglitazone in vitro. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 4 | Pioglitazone (2-400 microM) was incubated with isolated cytochrome P450 enzymes or human liver microsomes, some of them carrying either the CYP2C8*3/*3 genotype (and also the CYP2C9*2/*2 genotype) or the CYP2C8*1/*1 genotype (five samples each). | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 5 | Pioglitazone (2-400 microM) was incubated with isolated cytochrome P450 enzymes or human liver microsomes, some of them carrying either the CYP2C8*3/*3 genotype (and also the CYP2C9*2/*2 genotype) or the CYP2C8*1/*1 genotype (five samples each). | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 6 | Mean intrinsic clearance of pioglitazone to the metabolite M-IV was highest for CYP2C8 and CYP1A2 with 58 pmol M-IV/min/nmol CYP P450/microM pioglitazone each, 53 for CYP2D6*1, 40 for CYP2C19*1, and 34 for CYP2C9*2, respectively. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 7 | Mean intrinsic clearance of pioglitazone to the metabolite M-IV was highest for CYP2C8 and CYP1A2 with 58 pmol M-IV/min/nmol CYP P450/microM pioglitazone each, 53 for CYP2D6*1, 40 for CYP2C19*1, and 34 for CYP2C9*2, respectively. | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 8 | CYP2C8*1/*1 microsomes (25 +/- 4 pmol M-IV/min/mg protein/muM pioglitazone) showed lower intrinsic clearance of pioglitazone than CYP2C8*3/*3 microsomes (35 +/- 9, p = 0.04). | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 9 | CYP2C8*1/*1 microsomes (25 +/- 4 pmol M-IV/min/mg protein/muM pioglitazone) showed lower intrinsic clearance of pioglitazone than CYP2C8*3/*3 microsomes (35 +/- 9, p = 0.04). | Pioglitazone | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |