Title : Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.

Pub. Date : 2009 Jul 16

PMID : 19607716






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 An ancient primate-specific Alu short interspersed element (SINE) put the human CAMP gene under the regulation of the vitamin D pathway by providing a perfect vitamin D receptor binding element (VDRE) in its promoter. Vitamin D cathelicidin antimicrobial peptide Homo sapiens
2 Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D. Vitamin D cathelicidin antimicrobial peptide Homo sapiens
3 Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D. Vitamin D cathelicidin antimicrobial peptide Homo sapiens