Title : Calcineurin inhibitors promote chondrogenic marker expression of dedifferentiated human adult chondrocytes via stimulation of endogenous TGFbeta1 production.

Pub. Date : 2010 Jan

PMID : 19604038






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Addition of FK506 increased endogenous transforming growth factor 2 (TGF) beta1 expression on both mRNA and protein level. Tacrolimus transforming growth factor beta 1 Homo sapiens
2 The effect of FK506 on chondrogenic markers was abolished by addition of anti-TGFbeta1 antibody, indicating that the endogenous TGFbeta1 was necessary to increase chondrogenic marker expression. Tacrolimus transforming growth factor beta 1 Homo sapiens
3 The effect of FK506 on chondrogenic markers was abolished by addition of anti-TGFbeta1 antibody, indicating that the endogenous TGFbeta1 was necessary to increase chondrogenic marker expression. Tacrolimus transforming growth factor beta 1 Homo sapiens
4 In conclusion, inhibition of Cn activity by FK506 increases the expression of chondrogenic markers via endogenous TGFbeta1 production in human articular chondrocytes. Tacrolimus transforming growth factor beta 1 Homo sapiens