Title : Acute intrastriatal administration of quinolinic acid affects the expression of the coat protein AP-2 and its interaction with membranes.

Pub. Date : 2009 Oct

PMID : 19597933






5 Functional Relationships(s)
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1 Acute intrastriatal administration of quinolinic acid affects the expression of the coat protein AP-2 and its interaction with membranes. Quinolinic Acid transcription factor AP-2 alpha Homo sapiens
2 In this study, we demonstrated that acute intrastriatal administration of quinolinic acid (QUIN), an agonist of the N-methyl-D: -aspartate receptor, induces a decrease of the coat protein AP-2 expression and affects their interaction with membranes. Quinolinic Acid transcription factor AP-2 alpha Homo sapiens
3 In this study, we demonstrated that acute intrastriatal administration of quinolinic acid (QUIN), an agonist of the N-methyl-D: -aspartate receptor, induces a decrease of the coat protein AP-2 expression and affects their interaction with membranes. Quinolinic Acid transcription factor AP-2 alpha Homo sapiens
4 By western blot analysis we observed that at 24 h after QUIN intrastriatal injection, alpha1 subunit of AP-2 and alpha2, at lesser extent, were reduced in the striatal membranes. Quinolinic Acid transcription factor AP-2 alpha Homo sapiens
5 We concluded that QUIN may affect the endocytotic machinery of the striatum, by inducing changes in the AP-2 behaviour. Quinolinic Acid transcription factor AP-2 alpha Homo sapiens