Title : Effect of cyclic 3':5'-AMP derivatives prostaglandins and related agents on human chorionic gonadotropin secretion in human malignant trophoblast in culture.

Pub. Date : 1977 Jul

PMID : 195896






3 Functional Relationships(s)
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1 The secretion of human chorionic gonadotropin (hCG) is stimulated by addition of N6, O2"-dibutyryl cyclic 3":5"-AMP (dbcAMP) or theophylline to normal term placenta and human malignant trophoblast cells in vitro. Bucladesine chorionic gonadotropin subunit beta 5 Homo sapiens
2 The secretion of human chorionic gonadotropin (hCG) is stimulated by addition of N6, O2"-dibutyryl cyclic 3":5"-AMP (dbcAMP) or theophylline to normal term placenta and human malignant trophoblast cells in vitro. Bucladesine chorionic gonadotropin subunit beta 5 Homo sapiens
3 Whereas dbcAMP was the most potent agent in stimulating secretion of hCG, the N6--and O2"-monobutyryl derivatives of cAMP and phosphodiesterase inhibitors (theophylline, papaverine, 3-isobutyl-1-methylxanthine) also increased the secretion of the hormone. Bucladesine chorionic gonadotropin subunit beta 5 Homo sapiens