Pub. Date : 2009 Sep
PMID : 19587093
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells. | Etoposide | lysine methyltransferase 2A | Homo sapiens |
| 2 | We addressed whether: (i) low doses of etoposide promote MLL rearrangements in hESCs and hESCs-derived hematopoietic cells; (ii) MLL rearrangements are sufficient to confer hESCs with a selective growth advantage and (iii) continuous exposure to low doses of etoposide induces hESCs to acquire other chromosomal abnormalities. | Etoposide | lysine methyltransferase 2A | Homo sapiens |
| 3 | Etoposide induced MLL rearrangements in hESCs and their hematopoietic derivatives. | Etoposide | lysine methyltransferase 2A | Homo sapiens |
| 4 | These data show that chronic exposure of developmentally early stem cells to etoposide induces MLL rearrangements and make hESCs more prone to acquire other chromosomal abnormalities than postnatal CD34(+) cells, linking embryonic genotoxic exposure to genomic instability. | Etoposide | lysine methyltransferase 2A | Homo sapiens |