Title : Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.

Pub. Date : 2009 Sep 3

PMID : 19581934






5 Functional Relationships(s)
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1 Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells. Oxaliplatin tumor protein p53 Homo sapiens
2 Drug-resistant KB cells selected with cisplatin or oxaliplatin were found to have increased p53 levels and in oxaliplatin-selected cells, a larger p53 predominantly in the cytoplasm. Oxaliplatin tumor protein p53 Homo sapiens
3 Drug-resistant KB cells selected with cisplatin or oxaliplatin were found to have increased p53 levels and in oxaliplatin-selected cells, a larger p53 predominantly in the cytoplasm. Oxaliplatin tumor protein p53 Homo sapiens
4 Drug-resistant KB cells selected with cisplatin or oxaliplatin were found to have increased p53 levels and in oxaliplatin-selected cells, a larger p53 predominantly in the cytoplasm. Oxaliplatin tumor protein p53 Homo sapiens
5 In oxaliplatin-selected cells a single nucleotide deletion in the sequence-encoding amino acid 382, part of NLSIII, resulted in a frame shift and a 420 amino acid protein (p53(420)). Oxaliplatin tumor protein p53 Homo sapiens