Title : The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.

Pub. Date : 2009 Oct

PMID : 19578924






2 Functional Relationships(s)
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1 The COMT gene is considered as one of the prominent candidate genes for susceptibility to BP, and most studies focused a functional polymorphism in the gene: the Val/Met polymorphism (rs4680). Benzo(a)pyrene catechol-O-methyltransferase Homo sapiens
2 In conclusion, the low-activity allele (Met) of rs4680 in COMT gene possibly confers risk for bipolar disorder in the Han population, while it needs further evidence for concluding its association with BP in the Caucasian population. Benzo(a)pyrene catechol-O-methyltransferase Homo sapiens