Title : Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.

Pub. Date : 2009 Oct

PMID : 19574249






3 Functional Relationships(s)
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1 We also showed that c-Jun N-terminal kinase (JNK) is involved in ROS-dependent Bax activation. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
2 We also showed that c-Jun N-terminal kinase (JNK) is involved in ROS-dependent Bax activation. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
3 These results indicate that the natural triterpenoid pristimerin induces mitochondrial cell death through ROS-dependent activation of both Bax and PARP-1 in human cervical cancer cells and that JNK is involved in ROS-dependent Bax activation. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens