Title : A putative role for nicotinamide adenine dinucleotide-promoted nuclear protein modification in the antitumor activity of N-methyl-N-nitrosourea.

Pub. Date : 1977 Sep

PMID : 195715






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibition of poly(ADP-ribose) polymerase with nicotinamide results in extensive degradation of MNU-damaged DNA. Methylnitrosourea poly(ADP-ribose) polymerase 1 Homo sapiens
2 Taken as a whole, these results suggest that poly(ADP-ribose) polymerase may play a role in the repair of alkylation damage to cellular DNA and that the inhibition of this enzyme in vivo might be exploited to potentiate the antitumor and carcinogenic activities of MNU. Methylnitrosourea poly(ADP-ribose) polymerase 1 Homo sapiens