Title : Different enzyme kinetics of midazolam in recombinant CYP3A4 microsomes from human and insect sources.

Pub. Date : 2009

PMID : 19571438






1 Functional Relationships(s)
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1 The amounts of 1"- hydroxymidazolam and 4-hydroxymidazolam formed in CYP3A4 microsomes from transfected human liver epithelial cells (T5-3A4 microsomes) and baculovirus-infected insect cells (with and without coexpressed cytochrome b(5)) were analysed by LC-MS. 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens