Pub. Date : 2009 Oct
PMID : 19570948
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | hCtr1 is involved in the transport of platinum-based antitumor agents such as cisplatin (CDDP); however, the mechanisms that regulate hCtr1-mediated transport of these agents have not been well elucidated. | cddp | solute carrier family 31 member 1 | Homo sapiens |
| 2 | We compared the mechanisms of hCtr1-mediated transport of copper and CDDP. | cddp | solute carrier family 31 member 1 | Homo sapiens |
| 3 | We found that replacements of several methionine residues that are essential for hCtr1-mediated copper transport conferred a dominant-negative effect on the endogenous hCtr1"s function, resulting in reduced rates of Cu(I) and CDDP transport and increased resistance to the toxicities of copper and CDDP treatments. | cddp | solute carrier family 31 member 1 | Homo sapiens |
| 4 | We found that replacements of several methionine residues that are essential for hCtr1-mediated copper transport conferred a dominant-negative effect on the endogenous hCtr1"s function, resulting in reduced rates of Cu(I) and CDDP transport and increased resistance to the toxicities of copper and CDDP treatments. | cddp | solute carrier family 31 member 1 | Homo sapiens |
| 5 | We found that replacements of several methionine residues that are essential for hCtr1-mediated copper transport conferred a dominant-negative effect on the endogenous hCtr1"s function, resulting in reduced rates of Cu(I) and CDDP transport and increased resistance to the toxicities of copper and CDDP treatments. | cddp | solute carrier family 31 member 1 | Homo sapiens |
| 6 | We found that replacements of several methionine residues that are essential for hCtr1-mediated copper transport conferred a dominant-negative effect on the endogenous hCtr1"s function, resulting in reduced rates of Cu(I) and CDDP transport and increased resistance to the toxicities of copper and CDDP treatments. | cddp | solute carrier family 31 member 1 | Homo sapiens |