Pub. Date : 2009 Jul
PMID : 19562679
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Artemisinin--a possible CYP2B6 probe substrate? | artemisinin | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Correlations between the metabolic rate constant for artemisinin and the other CYP2B6 substrates were examined. | artemisinin | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | CONCLUSIONS: The rate of in vitro metabolism of artemisinin was correlated significantly to that of bupropion, propofol and efavirenz, suggesting artemisinin to be a potential alternative marker to assess CYP2B6 activity. | artemisinin | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Further studies characterizing the metabolic fate of artemisinin are needed in order to evaluate its utility as an in vitro and in vivo CYP2B6 probe substrate, since CYP2B6 might not be the only CYP isoform involved in the depletion of artemisinin. | artemisinin | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | Further studies characterizing the metabolic fate of artemisinin are needed in order to evaluate its utility as an in vitro and in vivo CYP2B6 probe substrate, since CYP2B6 might not be the only CYP isoform involved in the depletion of artemisinin. | artemisinin | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |