Title : Disruption of the OCH1 and MNN1 genes decrease N-glycosylation on glycoprotein expressed in Kluyveromyces lactis.

Pub. Date : 2009 Aug 20

PMID : 19559061






1 Functional Relationships(s)
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1 The N-linked oligosaccharides assembled on a secretory glycoprotein, HSA/GM-CSF in Kloch1 mutant, contained oligosaccharide Man(13-14)GlcNAc(2), and in Kloch1 mnn1 mutant, contained oligosaccharide Man(9-11)GlcNAc(2), whereas those in the wild-type strain, consisted of oligosaccharides with heterogeneous sizes, Man(>30)GlcNAc(2). n-linked oligosaccharides alpha-1,3-mannosyltransferase MNN1 Saccharomyces cerevisiae S288C