Pub. Date : 1991 Aug
PMID : 1954303
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Galanthamine, physostigmine and 9-amino-1,2,3,4-tetrahydroacridine (tacrine) were evaluated as inhibitors of human acetylcholinesterase activity from samples of postmortem human brain, fresh brain cortex biopsies and human erythrocytes. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | While physostigmine and tacrine acted equally on acetylcholinesterase from different sources, galanthamine was 10-fold less potent in inhibiting the enzyme activity from human brain that from human erythrocytes. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |