Title : Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP.

Pub. Date : 2009 Jul 15

PMID : 19542367






2 Functional Relationships(s)
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1 Additionally, cyclooxygenase-2 inhibition by NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide) reduced the TNF-alpha-induced increase in IL-6 mRNA/protein, which was restored by stimulation with PGE(2) or EP2, EP3, and EP4 agonists. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide interleukin 6 Homo sapiens
2 Additionally, cyclooxygenase-2 inhibition by NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide) reduced the TNF-alpha-induced increase in IL-6 mRNA/protein, which was restored by stimulation with PGE(2) or EP2, EP3, and EP4 agonists. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide interleukin 6 Homo sapiens