Title : Involvement of phosphatidylinositol 3-kinase in cAMP- and cGMP-induced duodenal epithelial CFTR activation in mice.

Pub. Date : 2009 Sep

PMID : 19535511






5 Functional Relationships(s)
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1 Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
2 Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
3 Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
4 Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
5 Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus