Title : Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes.

Pub. Date : 2009 Aug

PMID : 19531636






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The effects of SHH on wound healing and cutaneous NO function were markedly inhibited by SHH receptor inhibitor cyclopamine. cyclopamine sonic hedgehog Mus musculus
2 The effects of SHH on wound healing and cutaneous NO function were markedly inhibited by SHH receptor inhibitor cyclopamine. cyclopamine sonic hedgehog Mus musculus
3 After 24-h treatment in vitro, SHH (5-20 microg/ml) significantly increased cutaneous endothelial NOS protein expression, NOS activity and NO level in normal mice and STZ-induced diabetic mice in a concentration-dependent manner, an effect that was blunted by cyclopamine and NOS inhibitor N(omega)-nitro-L-arginine methyl ester. cyclopamine sonic hedgehog Mus musculus