Title : Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects.

Pub. Date : 2009 Aug

PMID : 19530977






1 Functional Relationships(s)
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1 Since cytochrome P450 enzymes CYP3A4 and CYP2B6 play a major role in prasugrel"s active metabolite formation, the effect of potent CYP induction by rifampin on the pharmacokinetics of prasugrel and on the pharmacodynamic response to prasugrel was evaluated in healthy male subjects. Prasugrel Hydrochloride cytochrome P450 family 2 subfamily B member 6 Homo sapiens