Pub. Date : 2009 Aug
PMID : 19522739
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. | Melatonin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Moreover, melatonin markedly activated c-JUN N-terminal kinase (JNK) and p38 kinase, whereas extracellular signal-regulated kinase (ERK) was not responsive to melatonin. | Melatonin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Moreover, melatonin markedly activated c-JUN N-terminal kinase (JNK) and p38 kinase, whereas extracellular signal-regulated kinase (ERK) was not responsive to melatonin. | Melatonin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. | Melatonin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. | Melatonin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Together, these results strongly suggest that JNK and p38 activation directly participate in apoptosis induced by melatonin. | Melatonin | mitogen-activated protein kinase 8 | Homo sapiens |