Pub. Date : 2010 Jan
PMID : 19515066
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin inhibits angiotensin II-induced cardiac cell hypertrophy: role of Homer 1a. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 2 | Homer 1a protein levels were upregulated following AngII-induced hypertrophy in H9C2 cells and neonatal rat cardiomyocytes, and these increases were augmented by simvastatin pretreatment. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 3 | Concomitantly, simvastatin pretreatment inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and AngII-induced hypertrophy. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 4 | The inhibitory effects of simvastatin against AngII-induced hypertrophy were attenuated by Homer 1a silencing, suggesting that simvastatin suppresses cardiac hypertrophy in a Homer 1a-dependent manner. | Simvastatin | angiotensinogen | Rattus norvegicus |
| 5 | The inhibitory effects of simvastatin against AngII-induced hypertrophy were attenuated by Homer 1a silencing, suggesting that simvastatin suppresses cardiac hypertrophy in a Homer 1a-dependent manner. | Simvastatin | angiotensinogen | Rattus norvegicus |