Title : Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.

Pub. Date : 2009 Oct 1

PMID : 19507250






1 Functional Relationships(s)
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1 Notably, RAD001 (10 nM) significantly augmented ATRA-induced expression of CCAAT/enhancer-binding protein epsilon (C/EBPepsilon) and p27(kip1) and downregulated levels of c-Myc in these cells. Tretinoin MYC proto-oncogene, bHLH transcription factor Homo sapiens