Title : In vitro evaluation of differences in phase 1 metabolism of ketamine and other analgesics among humans, horses, and dogs.

Pub. Date : 2009 Jun

PMID : 19496669






5 Functional Relationships(s)
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1 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
5 CONCLUSIONS AND CLINICAL RELEVANCE: Enzymes of the CYP 3A4 family and orthologs of CYP 2C9 were involved in ketamine metabolism in horses, dogs, and humans. Ketamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens