Pub. Date : 2009 Oct
PMID : 19491382
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peroxisome proliferator-activated receptor alpha plays a crucial role in L-carnitine anti-apoptosis effect in renal tubular cells. | Carnitine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | We found that the activity of the potential PGI(2) nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARalpha), was elevated by L-carnitine treatment. | Carnitine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | We found that the activity of the potential PGI(2) nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARalpha), was elevated by L-carnitine treatment. | Carnitine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | The siRNA-mediated blockage of PPARalpha considerably reduced the anti-apoptotic effect of L-carnitine. | Carnitine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 5 | In PPARalpha-deficient mice, L-carnitine treatment also lost the inhibitory effect on gentamicin-induced apoptosis in kidneys. | Carnitine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 6 | CONCLUSIONS: Based on these findings, we suggest that L-carnitine protects renal tubular cells from gentamicin-induced apoptosis through PGI(2)-mediated PPARalpha activation. | Carnitine | peroxisome proliferator activated receptor alpha | Mus musculus |