Pub. Date : 2010 Mar
PMID : 19481766
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism. | Cyclic AMP | interferon gamma | Homo sapiens |
| 2 | We previously showed that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding in primary hepatocytes but the signaling mechanisms responsible for this effect are not understood. | Cyclic AMP | interferon gamma | Homo sapiens |
| 3 | Immunofluorescent staining showed that cAMP inhibited IL-1beta plus IFNgamma-induced translocation of NF-kappaB into the nucleus. | Cyclic AMP | interferon gamma | Homo sapiens |
| 4 | Western blot analysis showed that the IL-1beta plus IFNgamma- induced phosphorylation and degradation of IkappaBa were markedly inhibited by cAMP. | Cyclic AMP | interferon gamma | Homo sapiens |
| 5 | Immunocomplex assay involving GST-IKK revealed that cAMP inhibited IL-1beta plus IFNgamma-induced IKK activity. | Cyclic AMP | interferon gamma | Homo sapiens |
| 6 | We demonstrated that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding due to its blockade of the upstream signal(s) leading to IkappaB phosphorylation and degradation, and is mediated by PKA-independent signaling pathways. | Cyclic AMP | interferon gamma | Homo sapiens |