Title : Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?

Pub. Date : 2009 Sep

PMID : 19480554






1 Functional Relationships(s)
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1 The results also indicate that skin sensitization and irritation reactions not only can be explained by the frequently in literature reported auto-oxidation of tea tree resulting in bioactive oxidized products, but also now by the formation of epoxide intermediates resulting from catalysed arene-epoxidation reactions by selected human cytochrome P450 enzymes which are also located in different organs in humans. Epoxy Compounds cytochrome P450 family 4 subfamily F member 3 Homo sapiens