Pub. Date : 2009 Jun
PMID : 19476543
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 2 | Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 3 | Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 4 | In both models nicotine stimulates TH gene transcription rate in a dose-dependent manner. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 5 | Nicotine elevates circulating glucocorticoids, which induce TH expression in some model systems. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 6 | We tested the hypothesis that the effect of nicotine on midbrain TH mRNA is mediated by the glucocorticoid receptor. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 7 | When rats are administered the glucocorticoid receptor antagonist mifepristone, the induction of TH mRNA by nicotine in both substantia nigra and ventral tegmentum is inhibited. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 8 | Our results are consistent with the hypothesis that nicotine induces TH mRNA in midbrain by elevating glucocorticoids, which then act on glucocorticoid receptors in dopamine neurons leading to transcriptional activation of the TH gene. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 9 | Our results are consistent with the hypothesis that nicotine induces TH mRNA in midbrain by elevating glucocorticoids, which then act on glucocorticoid receptors in dopamine neurons leading to transcriptional activation of the TH gene. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |