Pub. Date : 2009 Jul
PMID : 19468687
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calcium signaling-induced Smad3 nuclear accumulation induces acetylcholinesterase transcription in apoptotic HeLa cells. | Calcium | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | We previously showed that cellular calcium mobilization upregulated AChE expression by modulating promoter activity and mRNA stability. | Calcium | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | In this study, we have identified a potential Smad3/4 binding element, TGCCAGACA, located within the -601 to -571 bp fragment of the AChE promoter, as an important calcium response motif. | Calcium | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Calcium-induced AChE transcriptional activation was significantly blocked when the nuclear localization signal of Smad3 was destroyed. | Calcium | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Taken together, our data suggest Smad3 can regulate AChE transcriptional activation following calcium-induced nuclear accumulation. | Calcium | acetylcholinesterase (Cartwright blood group) | Homo sapiens |