Pub. Date : 2009 Sep
PMID : 19467701
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | BisGMA (0.1 mm) also stimulated ERK phosphorylation, PGE(2) production, COX-2 mRNA and protein expression as well as ROS production (as indicated by an increase in cellular DCF fluorescence) in dental pulp cells. | Bisphenol A-Glycidyl Methacrylate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
2 | Catalase (500 and 1000 U/ml) and U0126 (10 and 20 microm, a MEK inhibitor) effectively prevented the BisGMA-induced ERK activation, PGE(2) production and COX-2 expression. | Bisphenol A-Glycidyl Methacrylate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
3 | These results suggest that BisGMA released from composite resin may potentially affect the vitality of dental pulp and induce pulpal inflammation via stimulation of ROS production, MEK/ERK1/2 activation and subsequent COX-2 gene expression and PGE(2) production. | Bisphenol A-Glycidyl Methacrylate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |