Title : The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways.

Pub. Date : 2009 Sep

PMID : 19467701






3 Functional Relationships(s)
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1 BisGMA (0.1 mm) also stimulated ERK phosphorylation, PGE(2) production, COX-2 mRNA and protein expression as well as ROS production (as indicated by an increase in cellular DCF fluorescence) in dental pulp cells. Bisphenol A-Glycidyl Methacrylate mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Catalase (500 and 1000 U/ml) and U0126 (10 and 20 microm, a MEK inhibitor) effectively prevented the BisGMA-induced ERK activation, PGE(2) production and COX-2 expression. Bisphenol A-Glycidyl Methacrylate mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 These results suggest that BisGMA released from composite resin may potentially affect the vitality of dental pulp and induce pulpal inflammation via stimulation of ROS production, MEK/ERK1/2 activation and subsequent COX-2 gene expression and PGE(2) production. Bisphenol A-Glycidyl Methacrylate mitochondrially encoded cytochrome c oxidase II Homo sapiens