Pub. Date : 2009 Jul 1
PMID : 19464253
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 7-ketocholesterol | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Previously we observed enhanced degradation of Akt in P388D1 moncocyte/macrophages following treatment with 25-hydroxycholesterol (25-OH) or 7-ketocholesterol (7-KC). | 7-ketocholesterol | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | We show that treatment with 25-OH or 7-KC results in the accumulation of poly-ubiquitinated Akt, an effect that is enhanced by co-treatment with the proteasome inhibitor MG-132. | 7-ketocholesterol | thymoma viral proto-oncogene 1 | Mus musculus |