Title : Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease.

Pub. Date : 2011 May

PMID : 19464074






2 Functional Relationships(s)
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1 The results indicate that 6 weeks of nicotine treatment reduced the levels of Abeta(1-40) and BACE1 peptides in hippocampal area CA1 and prevented Abeta-induced impairment of learning and short-term memory. Nicotine carbonic anhydrase 1 Rattus norvegicus
2 Chronic nicotine also prevented the Abeta-induced inhibition of basal synaptic transmission and LTP in hippocampal area CA1. Nicotine carbonic anhydrase 1 Rattus norvegicus