Title : Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response.

Pub. Date : 2009 Jun 1

PMID : 19454717






3 Functional Relationships(s)
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1 Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response. Cyclosporine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 In TNF-alpha-treated cells, suppression of MCP-1 by CsA or FK506 was associated with blunted responses of NF-kappaB, the crucial regulator of MCP-1. Cyclosporine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 CsA and FK506, as well as other UPR inducers, caused up-regulation of C/EBP family members, especially C/EBPbeta and CHOP (C/EBP homologous protein), and overexpression of either C/EBPbeta or CHOP significantly attenuated TNF-alpha-triggered NF-kappaB activation. Cyclosporine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus