Title : Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis.

Pub. Date : 2009 Aug 15

PMID : 19442657






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that the interaction between hMSH5 and c-Abl confers ionizing radiation (IR)-induced apoptotic response by promoting c-Abl activation and p73 accumulation, and these effects are greatly enhanced in cells expressing hMSH5(P29S) (i.e. the hMSH5 variant possessing a proline to serine change within the N-terminal (Px)(5) dipeptide repeat). Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens