Title : The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase.

Pub. Date : 2009 Jun 1

PMID : 19435899






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As expected in this system, estrogen (E2) or androstenedione induced a proliferative response and increased ER-mediated transcription in ER-positive cell lines expressing aromatase. Androstenedione estrogen receptor 1 Homo sapiens
2 As expected in this system, estrogen (E2) or androstenedione induced a proliferative response and increased ER-mediated transcription in ER-positive cell lines expressing aromatase. Androstenedione estrogen receptor 1 Homo sapiens
3 However, surprisingly, in the presence of androstenedione, PTK/ZK suppressed both the androstenedione-stimulated proliferation and ER-mediated transcription. Androstenedione estrogen receptor 1 Homo sapiens