Title : MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells.

Pub. Date : 2009 Jun

PMID : 19424603






2 Functional Relationships(s)
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1 Ultraviolet radiation (UVB) and H2O2, two major factors causing RPE cell damage, induced AQP1 downregulation which was mediated by MEK/ERK activation. Hydrogen Peroxide aquaporin 1 (Colton blood group) Homo sapiens
2 Notably, pretreatment with all-trans retinoic acid attenuated UV- and H2O2-induced AQP1 downregulation and water permeability impairment. Hydrogen Peroxide aquaporin 1 (Colton blood group) Homo sapiens