Pub. Date : 2009 Jun
PMID : 19424582
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | From 117 kinds of chemicals (34 kinds of natural compounds that are obtained from herbal plants, 53 kinds of flavonoid, and 31 kinds of phenolic compounds), we find that quercetin works as an activator of p53 in K-Ras mutated cells but not in wild-type cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 2 | Treatment with quercetin can induce p53 target genes such as PUMA and p21. | Quercetin | tumor protein p53 | Homo sapiens |
| 3 | These results suggest that although quercetin has limitations for use as a therapeutic drug due to its broad effects, specific function of it on K-Ras-p53 may be useful for K-Ras-induced cancer prevention and therapy through further development. | Quercetin | tumor protein p53 | Homo sapiens |