Title : Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection.

Pub. Date : 2009 May

PMID : 19424057






1 Functional Relationships(s)
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1 Here, we investigated whether chronic restraint stress (14 days) and antidepressant treatment [desipramine (DMI), 10 mg/kg intraperitoneally] induce changes in animal behavior and hippocampal levels of phospho-ERK1/2 and its substrate phospho-cAMP response element-binding protein (CREB). Desipramine cAMP responsive element binding protein 1 Homo sapiens