Title : Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations.

Pub. Date : 2009 Jul

PMID : 19423748






3 Functional Relationships(s)
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1 Maintaining beta-TC-6 cells in the presence of a high level of thiamin led to a significant (P < 0.01) decrease in thiamin uptake, which was associated with a significant downregulation in level of expression of THTR-1 and THTR-2 at the protein and mRNA levels and a decrease in transcriptional (promoter) activity. Thiamine solute carrier family 19 (thiamine transporter), member 2 Mus musculus
2 Finally, confocal imaging of live beta-TC-6 cells showed that clinical mutants of THTR-1 have mixed expression phenotypes and all led to impairment in thiamin uptake. Thiamine solute carrier family 19 (thiamine transporter), member 2 Mus musculus
3 Furthermore, clinical mutants of THTR-1 impair thiamin uptake via different mechanisms. Thiamine solute carrier family 19 (thiamine transporter), member 2 Mus musculus