Pub. Date : 2009 Aug
PMID : 19420129
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prediction of the extent and time course of drug-drug interactions (DDIs) between the mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is confounded by time- and concentration-dependent clearance of the inhibitor. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Prediction of the extent and time course of drug-drug interactions (DDIs) between the mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is confounded by time- and concentration-dependent clearance of the inhibitor. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Enzyme kinetic parameters (k(inact) and K(I)) for DTZ and nd-DTZ were estimated in vitro and used to model the time course of changes in the amount of CYP3A4 in the liver and gut wall, which in turn, determined the nonlinear elimination of MDZ and DTZ, and the corresponding DDI. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Enzyme kinetic parameters (k(inact) and K(I)) for DTZ and nd-DTZ were estimated in vitro and used to model the time course of changes in the amount of CYP3A4 in the liver and gut wall, which in turn, determined the nonlinear elimination of MDZ and DTZ, and the corresponding DDI. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Moreover, model simulation suggested that both DTZ and nd-DTZ contributed to the overall inhibitory effect after DTZ administration, and the values of the in vitro estimated inhibition parameters and CYP3A4 turnover rate are critical for the prediction. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Moreover, model simulation suggested that both DTZ and nd-DTZ contributed to the overall inhibitory effect after DTZ administration, and the values of the in vitro estimated inhibition parameters and CYP3A4 turnover rate are critical for the prediction. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |