Title : Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.

Pub. Date : 2009 Jun 1

PMID : 19419861






1 Functional Relationships(s)
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1 The ester prodrugs (12a-c, 14a-c), which did not inhibit the COX-1 isozyme, exhibited modest inhibitory activity against the COX-2 isozyme. Esters mitochondrially encoded cytochrome c oxidase II Homo sapiens