Title : Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994).

Pub. Date : 2009 Aug

PMID : 19406663






7 Functional Relationships(s)
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1 Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994). Cadmium C-reactive protein Homo sapiens
2 This study explored the hypothesis that cadmium exposure is associated with elevated C-reactive protein (CRP) and fibrinogen, two risk factors for developing cardiovascular disease. Cadmium C-reactive protein Homo sapiens
3 This study explored the hypothesis that cadmium exposure is associated with elevated C-reactive protein (CRP) and fibrinogen, two risk factors for developing cardiovascular disease. Cadmium C-reactive protein Homo sapiens
4 METHODS: The current study investigated associations between urinary cadmium and the prevalence of elevated blood CRP (> or = 2.2 mg/L) and fibrinogen (> or = 10.35 micromol/L) using data from a sample of 6497 participants aged 40-79 in the Third National Health and Nutrition Examination Survey. Cadmium C-reactive protein Homo sapiens
5 RESULTS: Both simple and covariate-adjusted models indicated that urinary cadmium was associated with elevated CRP and fibrinogen in a dose-dependent fashion (p(trend)<0.05 for both). Cadmium C-reactive protein Homo sapiens
6 Adjusted odds ratios for increased CRP and fibrinogen comparing highest with lowest quartiles of urinary cadmium were 1.62 (95% confidence interval [CI], 1.24-2.12) and 2.12 (1.43-3.14), respectively. Cadmium C-reactive protein Homo sapiens
7 CONCLUSIONS: This analysis shows that cadmium exposure is associated with high prevalence of elevated CRP and fibrinogen. Cadmium C-reactive protein Homo sapiens