Pub. Date : 2009 Aug 10
PMID : 19397966
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 2 | Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 3 | Here we have analyzed the effects of BP on p53 related apoptotic proteins, cell cycle and cell death in MCF-7 cells. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 4 | PUMA-protein (p53 up-regulated modulator of apoptosis) levels were changed after BP exposure so that PUMA-alpha protein was statistically significantly increased whereas PUMA-beta protein was statistically significantly decreased. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 5 | Our results suggest that PUMA-alpha protein is involved in BP-induced cell death most likely through a p53 dependent apoptotic pathway. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |