Title : Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes.

Pub. Date : 1991 Nov

PMID : 1939646






3 Functional Relationships(s)
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1 The results showed that dexamethasone caused an increase in TGF beta production and a dose-dependent two to fourfold increase in TGF-beta 1 mRNA in activated as well as in unstimulated T cells, 1 h after exposure of the cultures to the steroid. Steroids transforming growth factor beta 1 Homo sapiens
2 The increase in TGF-beta 1 mRNA levels by dexamethasone was further potentiated two to threefold by cycloheximide, suggesting that the steroid effect may be due to inhibition of the synthesis of proteins that decrease TGF-beta 1 gene transcription or the stability of its transcripts. Steroids transforming growth factor beta 1 Homo sapiens
3 The increase in TGF-beta 1 mRNA levels by dexamethasone was further potentiated two to threefold by cycloheximide, suggesting that the steroid effect may be due to inhibition of the synthesis of proteins that decrease TGF-beta 1 gene transcription or the stability of its transcripts. Steroids transforming growth factor beta 1 Homo sapiens